Fluctuations, Pauses, and Backtracking in DNA Transcription
نویسندگان
چکیده
منابع مشابه
A dynamic model for processive transcription elongation and backtracking long pauses by multisubunit RNA polymerases.
RNA polymerases are enzymes that transcribe genes from DNA onto strands of RNA. The transcription elongation by multisubunit RNA polymerases is processive but nonuniform: one enzyme can translocate along the DNA template for thousands of nucleotide addition steps but, sometimes, it can enter backtracking long pauses. Here, we present a Brownian ratchet model for the processive transcription elo...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2008
ISSN: 0006-3495
DOI: 10.1529/biophysj.107.105767